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Published on: September 20, 2018

Cefditoren pivoxil associated rash and arthralgia in a child

Manab Nandy1, Ananya Mandal, Santanu K Tripathi

  • 1Department of Clinical and Experimental Pharmacology, Calcutta School of Tropical Medicine, Kolkata, India. manabn@gmail.com

Indian Journal of Pharmacology
|June 16, 2012
PubMed

Insights

Cefditoren pivoxil, an antibiotic for pediatric infections, may cause rash and joint pain. Discontinuation led to full recovery, indicating a probable adverse drug reaction in this pediatric case study.

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Pharmacology
  • Adverse Drug Reactions

Background:

  • Cefditoren pivoxil is an increasingly used oral antimicrobial for pediatric bacterial infections.
  • Adverse drug reactions (ADRs) in children require careful monitoring and assessment.

Purpose of the Study:

  • To report a case of rash and arthralgia associated with cefditoren pivoxil in a pediatric patient.
  • To assess the causality of the observed adverse event using standardized criteria.

Main Methods:

  • Case report of a four-year-old female child treated for lower respiratory tract infection.
  • Discontinuation of cefditoren pivoxil upon onset of symptoms.
  • Causality assessment using the WHO-UMC system and Naranjo's ADR probability scale.

Main Results:

  • The patient developed rash and arthralgia after cefditoren pivoxil administration.
  • Full recovery of knee joint function occurred within seven days of antibiotic discontinuation.
  • Causality was assessed as 'probable' by both WHO-UMC criteria and Naranjo's scale (score 7).

Conclusions:

  • Cefditoren pivoxil may be associated with adverse events such as rash and arthralgia in pediatric patients.
  • Prompt recognition and discontinuation of the antibiotic can lead to favorable outcomes.
  • This case highlights the importance of monitoring for ADRs with cefditoren pivoxil in children.

Keywords:
Arthralgiacefditoren pivoxilrash

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