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Updated: May 21, 2026
Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
Published on: June 8, 2019
Circulating DNA: diagnostic tool and predictive marker for overall survival of NSCLC patients
Raquel Catarino1, Ana Coelho, António Araújo
1Molecular Oncology Group Investigation Center, Portuguese Institute of Oncology, Porto, Portugal. raquelcatarino@yahoo.com
Purpose:
The purpose of our study was to determine whether the amounts of circulating DNA (cDNA) could discriminate between NSCLC patients and healthy individuals and assess its value as a prognostic marker of this disease.
Methods:
We conducted a study of 309 individuals and the cDNA levels were assessed through real-time PCR methodology.
Results:
We found increased cDNA levels in NSCLC patients compared to control individuals. We also found a decreased overall survival time in patients presenting high cDNA levels, when compared to lower cDNA concentrations.
Conclusions:
Quantification of cDNA may be a good tool for NSCLC detection with potential for clinical applicability.
