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Updated: May 21, 2026

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
Published on: October 4, 2021
Clinical aspects and management of levodopa-induced dyskinesia
Nicola Tambasco1, Simone Simoni, Erica Marsili
1Clinica Neurologica, Azienda Ospedaliera-Università di Perugia, S. Andrea delle Fratte, 06156 Perugia, Italy.
Abstract:
In Parkinson's disease, one of the most troublesome dilemmas is the treatment of levodopa-induced dyskinesia. After a few years, chronic treatment with levodopa is associated with the development of dyskinesias. Strategies to delay or to reduce dyskinesias are based on the change of levodopa dosing or the early use of dopamine agonists. Dopamine agonists with different pharmacological profile are available. Our paper was aimed to analyse the clinical impact and the management of dyskinesias with dopamine agonists.
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