[Possibilities of IVF in native cycle]

To evaluate the benefits and possibilities of the native cycle and/or minimal stimulation with subsequent use of methods of in-vitro fertilization.

Overview.

Pronatal, sro, Prague.

Native or modified cycles with minimal stimulation now experiencing a renaissance, mainly due to the onset of antagonists of gonadoliberines. Except for the standard controlled ovarian hyperstimulation protocols we use for acquiring of oocyte other different methods - free native cycles, ovulation induction with antiestrogens and/or adding the minimum doses of gonadotropins. Concomitant use of antagonists prevents premature peak of luteinizing hormone, that was previously characteristic for these procedures. Native cycles we can use virtually for all the factors of infertility. Pregnancy rate per cycle is about 17%, but the cumulative pregnancy rate after three consecutive cycles reaches over 30%.

Native cycle and its current modifications and subsequent in vitro fertilization offers the benefit of minimal consumption of drugs and the practical absence of side effects. It is characterized by short duration, lower price and the possibility of repetition each month. Virtually eliminates the occurrence of multiple pregnancies. Its efficiency is however limited and is characterized by a high number of cancellations. The cumulative pregnancy rate per embryo transfer is comparable with pregnancy rate of conventional stimulation protocols.