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Related Experiment Video

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Oral Biofilm Formation on Different Materials for Dental Implants
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Published on: June 24, 2018

Microbial biofilms on facial prostheses.

Nina Ariani1, Arjan Vissink, Robert P van Oort

  • 1Department of Biomedical Engineering, W.J. Kolff Institute, University Medical Center Groningen and the University of Groningen, Groningen, The Netherlands.

Biofouling
|June 19, 2012
PubMed
Summary
This summary is machine-generated.

Microbial biofilms on silicone facial prostheses show increased colonization, with yeasts like Candida spp. exclusively found on prosthesis-covered skin. Prostheses create a niche for opportunistic pathogens, altering skin microbial composition.

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Area of Science:

  • Microbiology
  • Biomaterials Science
  • Dermatology

Background:

  • Silicone rubber facial prostheses can harbor microbial biofilms.
  • The microbial flora on these prostheses may differ from healthy skin.
  • Understanding biofilm composition is crucial for prosthesis care and patient health.

Purpose of the Study:

  • To investigate and compare the microbial biofilm composition on silicone rubber facial prostheses with that on healthy and prosthesis-covered skin.
  • To identify specific microorganisms, including yeasts and bacteria, present in these biofilms.
  • To assess the impact of prosthesis use on skin microbial diversity and colonization.

Main Methods:

  • Scanning electron microscopy (SEM) for visualizing biofilm structure and surface deterioration.
  • Microbial culturing to identify and quantify yeasts and bacteria.
  • Denaturing gradient gel electrophoresis (DGGE) to analyze bacterial diversity and community composition.

Main Results:

  • SEM revealed mixed bacterial and yeast biofilms and surface deterioration on prostheses.
  • Microbial colonization was significantly higher on prosthesis-covered skin than on healthy skin.
  • Candida spp. were exclusively isolated from prosthesis-covered skin and prostheses, indicating a specific niche.
  • Prosthesis biofilms exhibited the least diversity (DGGE), while prosthesis-covered skin showed the most.
  • Bacterial diversity consistently exceeded yeast diversity across all sample types.

Conclusions:

  • Occlusion by facial prostheses creates a favorable environment for opportunistic pathogens like Candida spp. and Staphylococcus aureus.
  • While biofilm composition is comparable across healthy skin, skin under prostheses, and prostheses themselves, microbial numbers differ significantly.
  • These findings highlight the need for effective management strategies to mitigate microbial proliferation on facial prostheses and surrounding skin.