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Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
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Published on: February 1, 2019

Natural antisense transcripts in fungi.

Michael E Donaldson1, Barry J Saville

  • 1Environmental and Life Sciences Graduate Program, Trent University, Peterborough, ON, Canada K9J 7B8.

Molecular Microbiology
|June 19, 2012
PubMed
Summary
This summary is machine-generated.

Natural antisense transcripts (NATs) in fungi regulate gene expression through various mechanisms. Further research into fungal NATs is needed to uncover their diverse roles in core life functions and responses to stimuli.

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Last Updated: May 21, 2026

Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
10:21

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Published on: February 1, 2019

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Area of Science:

  • Molecular Biology
  • Mycology
  • Genetics

Background:

  • Fungi serve as model organisms for studying eukaryotic molecular processes.
  • Natural antisense transcripts (NATs) have been identified in fungi, revealing novel gene expression control mechanisms.
  • These mechanisms include transcriptional interference, chromatin remodeling, and double-stranded RNA (dsRNA) formation.

Purpose of the Study:

  • To provide an overview of NAT-related gene expression control mechanisms in fungi.
  • To discuss specific functions of fungal NATs within the broader context of gene regulation.
  • To highlight the significance of transcriptome analyses in uncovering fungal NATs and their potential roles.

Main Methods:

  • Literature review of existing studies on fungal NATs.
  • Analysis of transcriptome data to identify and characterize NATs in diverse fungal species.
  • Correlation of NAT expression timing with fungal life cycle events.

Main Results:

  • Transcriptome analyses have identified a substantial number of NATs across various fungal groups.
  • The expression patterns of many NATs suggest involvement in fundamental biological processes like environmental response and sexual reproduction.
  • A significant number of NATs with unknown functions were discovered, indicating potential for novel regulatory roles.

Conclusions:

  • Fungal NATs represent a significant layer of gene expression regulation.
  • Further investigation into the functions of uncharacterized NATs is crucial for understanding fungal biology.
  • This field holds promise for discovering novel mechanisms of gene control and targeted biological responses in fungi.