Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Plasma histamine and exercise-induced bronchospasm].

T Bury1, F Pirnay, J L Corhay

  • 1Service de Pneumologie, CHU Liège, Sart Tilman, Belgique.

Revue Des Maladies Respiratoires
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Chronic obstructive pulmonary disease. A chronic inflammatory disease].

Revue medicale de Liege·2022
Same author

[Fixed combination of budesonide, formoterol, glycopyrronium for the treatment of severe COPD : Trixeo Aerosphere®].

Revue medicale de Liege·2022
Same author

[Feasibility and effectiveness study of a simplified mobile self-education and self-monitoring application for patients with severe chronic obstructive pulmonary disease].

Revue medicale de Liege·2022
Same author

White Blood Cells in Patients Treated with Programmed Cell Death-1 Inhibitors for Non-small Cell Lung Cancer.

Lung·2021
Same author

[Managing of dyspnea in oncology].

Revue medicale de Liege·2021
Same author

[Pre-cancerous lung lesions and lung cancer screening].

Revue medicale de Liege·2021

Exercise-induced bronchospasm may involve mast cell activation. Studies show asthmatic individuals experience elevated histamine levels during exercise, suggesting a role for these cells in airway constriction.

Area of Science:

  • Exercise physiology
  • Allergy and immunology
  • Respiratory medicine

Background:

  • The exact causes of exercise-induced bronchospasm (EIB) remain unclear, with multiple contributing factors suspected.
  • Mast cells are immune cells known to release histamine and other mediators involved in allergic reactions and inflammation.

Purpose of the Study:

  • To investigate the role of mast cells in the pathogenesis of EIB.
  • To assess mast cell activation by measuring plasma histamine levels during exercise challenges.

Main Methods:

  • Plasma histamine levels were measured in asthmatic and normal subjects during repeated exercise tests.
  • Correlation between bronchospasm occurrence and histamine level fluctuations was analyzed.

Main Results:

Related Experiment Videos

  • Asthmatic subjects who experienced EIB showed a significant threefold increase in serum histamine levels.
  • Normal subjects exhibited minimal changes in histamine levels during exercise.
  • A direct correlation was observed between the onset of EIB and elevated plasma histamine.

Conclusions:

  • Mast cell activation and subsequent mediator release appear to play a significant role in the development of exercise-induced bronchospasm.
  • These findings suggest that targeting mast cell activity could be a therapeutic strategy for EIB.