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Updated: May 21, 2026
12:24
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
CD40 ligand (CD154) involvement in platelet transfusion reactions
J Sahler1, S Spinelli, R Phipps
1Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, 601, Elmwood Avenue Rochester, New York 14642, USA.
Summary
Platelet transfusions can cause adverse reactions due to soluble CD40 ligand (sCD40L) released during storage. High sCD40L levels in transfused platelets may trigger inflammation and vascular damage in recipients.
Area of Science:
- Hematology
- Immunology
- Transfusion Medicine
Background:
- Platelet transfusions are common but can cause adverse reactions.
- Stored platelet concentrates release pro-inflammatory and pro-thrombotic mediators.
- Soluble CD40 ligand (sCD40L) is a key mediator implicated in these reactions.
Purpose of the Study:
- To investigate the role of soluble CD40 ligand (sCD40L) in adverse transfusion reactions.
- To understand the mechanism by which sCD40L contributes to inflammation and vascular damage.
Main Methods:
- Review of clinical trials, in vitro, and animal studies.
- Analysis of mediators in platelet concentrate supernatant.
- Correlation of sCD40L levels with adverse transfusion reactions in retrospective studies.
Main Results:
- Stored platelets release significant amounts of cytokines, chemokines, and prostaglandins.
- Soluble CD40 ligand (sCD40L) signaling promotes inflammation, pro-thrombotic events, and leukocyte-endothelial interactions.
- Elevated sCD40L levels in platelet concentrates correlate with adverse transfusion reactions.
Conclusions:
- Transfusion of platelets with high sCD40L levels may cause a "double-hit" effect.
- This "double-hit" can incite inflammation and vascular damage in recipients, especially those with pre-existing vascular conditions.
- sCD40L is a critical mediator contributing to transfusion-related adverse events.
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