Integrating risks for type 2 diabetes across childhood: a life course perspective

Rika Tanda1, Pamela J Salsberry

  • 1The Ohio State University, College of Nursing, Columbus, OH, USA. tanda.3@buckeyemail.osu.edu

Insights

Type 2 diabetes in children is linked to weight gain. Early and continuous interventions throughout childhood are crucial for prevention and management of this growing epidemic.

Area of Science:

  • Pediatric Endocrinology
  • Public Health

Background:

  • Childhood obesity is a significant risk factor for Type 2 diabetes (T2DM).
  • The physiological link between increased weight and T2DM is well-established in pediatric populations.
  • T2DM is emerging at unprecedented rates among children globally.

Purpose of the Study:

  • To review cumulative risk factors and mechanisms of T2DM in children.
  • To emphasize the importance of interventions across all childhood stages.
  • To introduce a framework for assessing individual T2DM risk in children.

Main Methods:

  • Literature review of T2DM risk factors and mechanisms in childhood.
  • Application of Halfon and Hochstein's framework for risk assessment.
  • Analysis of intervention points throughout pediatric development.

Main Results:

  • Identified cumulative risk factors contributing to pediatric T2DM.
  • Highlighted the necessity of a lifelong perspective for T2DM prevention.
  • Demonstrated the utility of a specific framework for nursing practitioners and researchers.

Conclusions:

  • Interventions for pediatric T2DM must be implemented early and sustained throughout childhood.
  • Understanding individual risk using frameworks like Halfon and Hochstein's is key for effective management.
  • Addressing the 'twin epidemic' of obesity and T2DM requires a comprehensive, long-term strategy.

Related Concept Videos

Type II Diabetes I: Introduction01:26

Type II Diabetes I: Introduction

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance, in which target tissues such as the liver, muscle, and adipose tissue respond poorly to insulin. It is also associated with inadequate compensatory insulin secretion, where pancreatic β-cells fail to produce sufficient insulin. Together, these abnormalities lead to persistent hyperglycemia.EtiologyT2DM develops through a complex interaction of genetic predisposition and environmental or...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...