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Related Experiment Video

Updated: May 21, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Immunotherapies in rheumatologic disorders.

Anne V Miller¹, Sriya K M Ranatunga

¹Division of Rheumatology, Department of Internal Medicine, Southern Illinois University School of Medicine, PO Box 19636, Springfield, IL 62794-9636, USA. amiller3@siumed.edu

The Medical Clinics of North America

|June 19, 2012

Summary

This summary is machine-generated.

This review explores immunotherapies for rheumatic diseases, examining how older treatments and new biologics target immune system dysregulation in conditions like rheumatoid arthritis and lupus.

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Adoptive Immunotherapy of iNKT Cells in Glucose-6-Phosphate Isomerase (G6PI)-Induced RA Mice

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Area of Science:

Rheumatology
Immunology
Pharmacology

Background:

Rheumatology research focuses on immune dysregulation in autoimmune diseases.
Understanding mechanisms of older therapies is crucial.
Biologics offer targeted approaches for specific immune defects.

Purpose of the Study:

To review current standard and biologic immunotherapies for rheumatic diseases.
To correlate treatment mechanisms with immune dysfunctions in autoimmune syndromes.
To highlight applications in rheumatoid arthritis and systemic lupus erythematosus.

Main Methods:

Literature review of immunotherapies in rheumatology.
Analysis of established and novel treatment mechanisms.
Correlation of mechanisms with pathophysiology of major autoimmune diseases.

Main Results:

Older therapies' immune-modulating mechanisms are being elucidated.
Biologics are designed for specific immune targets.
Understanding mechanisms aids in treating rheumatoid arthritis and systemic lupus erythematosus.

Conclusions:

Current immunotherapies for rheumatic diseases are evolving.
Targeting specific immune pathways is key for effective treatment.
Further research will refine understanding and application of these therapies.