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Updated: May 21, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters
Dominic Thibeault1, Charles Gauthier, Jean Legault
1Université du Québec à Chicoutimi, Laboratoire d'analyse et de séparation des essences végétales (LASEVE), Département des sciences fondamentales, 555 boul. de l'Université, Chicoutimi (Québec), Canada G7H 2B1.
Abstract:
A new series of betulinic acid and betulin derivatives were synthesized by introducing a D-glycerol moiety at the C-3 and/or C-28 positions of the lupane skeleton. The resulting glyceryl esters were evaluated in vitro for their cytotoxic activity against A549, DLD-1 and WS1 human cell lines. The structure-activity relationships study revealed that the incorporation of a glycerol unit at the C-3 or C-28 position of the lupane core resulted in compounds exhibiting potent cytotoxic activity together with decreased liposolubility.
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