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No effect of antidepressant treatment on elevated serum ceruloplasmin level in patients with first-episode

Mehmet Cemal Kaya1, Yasin Bez, Salih Selek

  • 1Department of Psychiatry, Dicle University School of Medicine, Diyarbakir, Turkey.

Archives of Medical Research
|June 19, 2012
PubMed

Insights

Serum ceruloplasmin levels are elevated in patients with depression and remain high even after successful antidepressant treatment. This study investigated ceruloplasmin in depression and its response to treatment.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Psychiatry

Background:

  • Ceruloplasmin, an antioxidant acute phase reactant, is elevated in schizophrenia and OCD.
  • Limited research exists on ceruloplasmin levels in major depressive disorder.

Purpose of the Study:

  • To determine serum ceruloplasmin levels in depressed patients before and after treatment.
  • To compare these levels with healthy controls.
  • To assess the association between ceruloplasmin and treatment response.

Main Methods:

  • 19 patients with major depressive disorder and 40 healthy controls were studied.
  • Patients received 8 weeks of naturalistic antidepressant treatment.
  • Serum ceruloplasmin and Hamilton Depression Rating Scale (HAM-D) scores were measured pre- and post-treatment.

Main Results:

  • Depressed patients had significantly higher serum ceruloplasmin levels than controls, both before and after treatment.
  • Ceruloplasmin levels did not significantly change after treatment, despite clinical improvement.
  • No correlation was found between HAM-D scores, treatment response, and ceruloplasmin levels.

Conclusions:

  • Serum ceruloplasmin levels are higher in patients with depression compared to healthy individuals.
  • These elevated levels persist despite acute antidepressant treatment and clinical improvement.
  • Ceruloplasmin levels do not appear to correlate with depression severity or treatment response.
Abstract

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