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Heparin effect on bone density.

J S Ginsberg1, G Kowalchuk, J Hirsh

  • 1Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Thrombosis and Haemostasis
|October 22, 1990
PubMed
Summary
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Long-term heparin therapy in premenopausal women may reduce bone density, increasing fracture risk. While no symptomatic fractures occurred, lower bone density was observed in treated women compared to controls.

Area of Science:

  • Endocrinology
  • Rheumatology
  • Pharmacology

Background:

  • Long-term heparin therapy is used for various medical conditions.
  • Osteoporosis and reduced bone density are significant health concerns, particularly in women.
  • The effects of prolonged heparin use on bone health in premenopausal women are not well-established.

Purpose of the Study:

  • To estimate the risks of symptomatic osteoporosis and reduced bone density in premenopausal women receiving long-term heparin therapy.
  • To compare bone density and fracture incidence between premenopausal women on long-term heparin and a matched control group.

Main Methods:

  • A cohort study evaluated 61 premenopausal women treated with long-term heparin (cases) and matched controls.
  • Bone density was assessed using dual photon absorptiometry (lumbar spine) and single photon absorptiometry (wrist).

Related Experiment Videos

  • Lateral radiography of the thoracolumbar spine was performed to detect silent fractures.

    • Main Results:

    • No symptomatic fractures were reported in the heparin-treated group (0 of 61).
    • A significantly higher proportion of cases exhibited bone density below pre-defined levels compared to controls.
    • The study identified a potential link between long-term heparin use and decreased bone density.

    Conclusions:

    • Long-term heparin therapy in premenopausal women is associated with reduced bone density.
    • While symptomatic fractures were not observed, the decrease in bone density may predispose women to future fractures.
    • This potential risk should be considered in the clinical management of women on long-term heparin therapy.