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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

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Relationship between obstructive sleep apnea severity index and left ventricular function and volume.

Nejat Altintas¹, Ekrem Aslan, Aysen Helvaci

¹School of Medicine, Department of Pulmonary and Sleep Medicine, Mayis University, Samsun, Turkey. nejataltintas@gmail.com

Annals of Saudi Medicine

|June 19, 2012

Summary

Obstructive sleep apnea (OSA) is linked to worsening heart abnormalities. Severe OSA patients showed increased left ventricular mass and a higher myocardial performance index (MPI), suggesting cardiac impact.

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Published on: October 28, 2020

Area of Science:

Cardiology
Sleep Medicine
Echocardiography

Background:

Obstructive sleep apnea (OSA) is a significant risk factor for cardiovascular diseases, including hypertension, coronary heart disease, heart failure, and stroke.
The association between OSA severity and cardiac structural and functional changes requires further investigation.

Purpose of the Study:

To evaluate left ventricular mass (LVM) and myocardial performance index (MPI) in patients diagnosed with obstructive sleep apnea.
To determine if cardiac abnormalities correlate with the severity of OSA.

Main Methods:

A cross-sectional study involving 40 patients evaluated for OSA.
Patients underwent polysomnography to determine apnea-hypopnea index (AHI) and echocardiography for cardiac assessments.
Left ventricular mass index (LVMI) and MPI were calculated based on echocardiographic measurements.

Main Results:

Patients with severe OSA exhibited significantly higher interventricular septum thickness, left ventricular posterior wall thickness, LVM, and LVMI compared to mild and moderate OSA groups.
The myocardial performance index (MPI) was significantly elevated in severe OSA patients compared to mild OSA patients.
Blood pressure was also higher in the severe OSA group.

Conclusions:

Obstructive sleep apnea is associated with measurable cardiac abnormalities, with increasing severity correlating with greater cardiac impact.
The myocardial performance index (MPI) shows potential as a surrogate outcome measure in future research on OSA and cardiovascular health.