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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Neurotransmitters01:31

Neurotransmitters

Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR activation may...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...

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Related Experiment Video

Updated: May 21, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

Reelin and its complex involvement in brain development and function.

Silvia Lakatosova1, Daniela Ostatnikova

  • 1Institute of Physiology, Comenius University Faculty of Medicine, Bratislava, Slovakia. silvia.lakatosova@gmail.com

The International Journal of Biochemistry & Cell Biology
|June 19, 2012
PubMed
Summary
This summary is machine-generated.

Reelin, a key neuroprotein, is vital for brain development and function. Its deficits are linked to neuropsychiatric disorders, highlighting its diagnostic and therapeutic potential.

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Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

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Related Experiment Videos

Last Updated: May 21, 2026

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development
13:47

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

Published on: April 3, 2013

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
10:25

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
10:45

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Neurodevelopmental Biology

Background:

  • Reelin is a crucial neuroprotein involved in neurodevelopment, regulating neuronal migration and positioning in the neocortex and cerebellar cortex.
  • Postnatally, Reelin influences dendritic and axonal growth, synaptogenesis, neurotransmission, and synaptic plasticity essential for learning and memory.
  • The complex role of Reelin is continually being uncovered through ongoing research.

Purpose of the Study:

  • To explore the multifaceted functions of the neuroprotein Reelin.
  • To investigate the association between Reelin deficits and neuropsychiatric disorders.
  • To assess the potential of Reelin in diagnostics and therapeutics for neurological conditions.

Main Methods:

  • Literature review of studies on Reelin's function.
  • Analysis of genetic variants associated with Reelin.
  • Examination of Reelin's role in the pathogenesis of neuropsychiatric disorders.

Main Results:

  • Reelin plays a critical role in neuronal development and postnatal brain functions, including synaptic plasticity.
  • Deficits in Reelin have been observed in schizophrenia, bipolar disorder, and autism.
  • Genetic variations in Reelin are linked to these disorders and can affect symptom severity.

Conclusions:

  • Reelin's complex functions are vital for normal brain development and function.
  • Reelin is a significant factor in the pathogenesis of several neuropsychiatric disorders.
  • Reelin represents a promising candidate for future diagnostic and therapeutic strategies, warranting further investigation.