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Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

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MScreen: an integrated compound management and high-throughput screening data storage and analysis system.

Renju T Jacob¹, Martha J Larsen, Scott D Larsen

¹Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. renjutj@umich.edu

Journal of Biomolecular Screening

|June 19, 2012

Summary

This summary is machine-generated.

MScreen is an open-source application designed to manage high-throughput screening (HTS) data, including chemical libraries and siRNA. It facilitates efficient data handling and analysis for academic researchers, improving the identification of potential drug candidates and experimental tools.

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Area of Science:

Biochemistry
Molecular Biology
Drug Discovery

Background:

High-throughput screening (HTS) is crucial for identifying drug candidates and biological probes.
Managing the vast data generated by HTS presents significant challenges in academic research.
Existing tools often lack comprehensive features for both chemical and siRNA screening data.

Purpose of the Study:

To introduce MScreen, a web-based, open-source cheminformatics application.
To provide a solution for managing chemical libraries and siRNA screening data.
To facilitate efficient HTS data handling, analysis, and collaboration in academic settings.

Main Methods:

MScreen offers a web-based platform for chemical library and siRNA plate management.
It supports primary HTS and dose-response data handling, including structure search.
Features include automated dose-response fitting, quality control, and user/target/assay administration.

Main Results:

MScreen enables secure or open sharing of project data for collaborative analysis.
Unique features include specialized plate creation and formatting for compounds, mixtures, and siRNAs.
Automated data fitting and QC streamline the evaluation of screening results.

Conclusions:

MScreen provides an effective solution for HTS data management and analysis in academia.
The application facilitates efficient viewing and evaluation of screening data for follow-up studies.
MScreen supports the identification of compounds with desired selectivity and aids in experimental tool discovery.