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Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

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Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Chronic Inflammation: Introduction

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Detailed Structure and Function of Lymph Nodes01:23

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Related Experiment Video

Updated: May 21, 2026

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

Granulomatous lymphadenitis.

Shigeyuki Asano1

  • 1Department of Pathology, Iwaki Kyoritsu General Hospital, Iwaki, Japan. byori@iwaki-kyoritsu.fukushima.jp

Journal of Clinical and Experimental Hematopathology : JCEH
|June 19, 2012
PubMed
Summary

This review details granulomatous lymphadenitis (GLA), classifying it into infectious and noninfectious types. Understanding characteristic histological findings aids accurate pathological diagnosis and precise treatment for various GLA conditions.

Area of Science:

  • Pathology
  • Immunology
  • Infectious Diseases

Background:

  • Granulomatous lymphadenitis (GLA) encompasses diverse conditions, broadly categorized into infectious and noninfectious etiologies.
  • Noninfectious GLA includes sarcoidosis and sarcoid-like reactions, while infectious GLA comprises suppurative and nonsuppurative lymphadenitis.
  • Accurate differentiation of GLA subtypes is crucial for effective patient management.

Purpose of the Study:

  • To review and describe representative types of granulomatous lymphadenitis (GLA).
  • To highlight the distinct histological features associated with various GLA classifications.
  • To emphasize the importance of pathological diagnosis for guiding treatment strategies.

Main Methods:

  • Review of literature on granulomatous lymphadenitis.

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Last Updated: May 21, 2026

Murine Bilateral Renal Lymphadenectomy
06:31

Murine Bilateral Renal Lymphadenectomy

Published on: December 30, 2025

  • Classification of GLA into noninfectious (sarcoidosis, sarcoid-like reaction) and infectious (suppurative, nonsuppurative) categories.
  • Description of characteristic histological findings for each GLA type, including cellular infiltrates, granuloma formation, and presence/absence of necrosis.

    • Main Results:

    • Noninfectious GLA: Sarcoidosis (unknown cause, good prognosis) and sarcoid-like reactions (biological defense mechanism).
    • Infectious GLA: Suppurative LA (e.g., tularemia, cat scratch disease, Yersinia) characterized by follicular hyperplasia, sinus histiocytosis, and sometimes abscesses; Nonsuppurative LA (e.g., tuberculosis, BCG-histiocytosis, toxoplasmosis) linked to delayed hypersensitivity or protozoan infections.
    • Specific lymph node regions are often affected (e.g., axillary/cervical for tularemia/cat scratch disease, mesenteric for Yersinia, cervical for tuberculosis).

    Conclusions:

    • Granulomatous lymphadenitis presents with diverse histological patterns.
    • Distinguishing features such as the presence of monocytoid B lymphocytes (MBLs), granuloma morphology, and necrosis aid in classifying GLA.
    • Accurate pathological diagnosis based on these histological findings is essential for determining appropriate and precise treatment.