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Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Mouse models of breast cancer metastasis to bone

Kelsi L Kretschmann1, Alana L Welm

  • 1Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Cancer Metastasis Reviews
|June 19, 2012
PubMed

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...