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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

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Related Experiment Video

Updated: May 21, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Regression of atherosclerosis.

Benoit J Arsenault1, Ekaterini A Kritikou, Jean-Claude Tardif

  • 1Montreal Heart Institute, Université de Montréal, 5000 Belanger Street, Montreal, Québec, Canada.

Current Cardiology Reports
|June 19, 2012
PubMed
Summary

Novel drugs and advanced imaging techniques are emerging to combat atherosclerotic cardiovascular disease (CVD). This review highlights progress in treating atherosclerosis and assessing its progression for better patient outcomes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Medical Imaging

Background:

  • Atherosclerotic cardiovascular disease (CVD) is a major cause of premature death and hospitalization.
  • Current treatments aim to reduce mortality and promote regression of atherosclerotic lesions.

Purpose of the Study:

  • To review the latest advancements in CVD treatment and management.
  • To highlight novel drugs targeting atherosclerosis.
  • To discuss current and emerging imaging techniques for monitoring atherosclerosis progression.

Main Methods:

  • Review of clinical trials focusing on hard end points (mortality, myocardial infarction).
  • Analysis of trials using surrogate end points with imaging biomarkers.
  • Examination of drug therapies targeting low-density lipoproteins, high-density lipoproteins, inflammation, and oxidation.

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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Published on: February 20, 2019

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Last Updated: May 21, 2026

Quantification of Atherosclerosis in Mice
06:59

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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

Main Results:

  • Statins have demonstrated efficacy in promoting atherosclerosis regression.
  • Several novel drug candidates targeting different pathways are under investigation.
  • Imaging biomarkers offer rapid assessment of cardiovascular drug efficacy.

Conclusions:

  • New therapeutic strategies and advanced imaging are crucial for managing atherosclerotic CVD.
  • Personalized approaches combining novel drugs and precise imaging will improve atherosclerosis treatment.
  • Continued research is essential to reduce the burden of cardiovascular disease.