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Related Concept Videos

Sample Handling01:02

Sample Handling

Transportation of samples from the collection point to the laboratory, as well as storage and preservation techniques, are crucial for maintaining sample integrity and ensuring accurate and reliable test results.
Samples should be transported carefully from collection points to the laboratory. They should be properly sealed and clearly labeled to prevent cross-contamination. To preserve the sample integrity, optimal temperature conditions during transport are essential. This could involve using...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

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Related Experiment Video

Updated: May 21, 2026

Enumeration of Major Peripheral Blood Leukocyte Populations for Multicenter Clinical Trials Using a Whole Blood Phenotyping Assay
14:45

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Published on: September 16, 2012

Quality standards for sample processing, transportation, and storage in hemostasis testing.

Dorothy M Adcock Funk1, Giuseppe Lippi, Emmanuel J Favaloro

  • 1Esoterix Inc., Englewood, Colorado 80112, USA. adcockd@labcorp.com

Seminars in Thrombosis and Hemostasis
|June 19, 2012
PubMed
Summary
This summary is machine-generated.

Preanalytical variables significantly impact hemostasis test results. Proper sample handling, including temperature control and centrifugation, is crucial for accurate diagnostic outcomes.

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Hematology

Background:

  • Hemostasis testing relies on blood samples collected in sodium citrate anticoagulant.
  • Preanalytical variables in sample processing, transport, and storage can compromise test accuracy.
  • Understanding these variables is essential for reliable laboratory diagnostics.

Purpose of the Study:

  • To identify critical preanalytical variables affecting hemostasis testing.
  • To discuss the impact of sample handling on assay results.
  • To recommend ideal conditions for sample processing, transport, and storage.

Main Methods:

  • Review of preanalytical factors influencing hemostasis sample integrity.
  • Analysis of temperature effects (room temperature, refrigerated, frozen) on sample stability.
  • Evaluation of centrifugation methods and automated processing impacts.

Main Results:

  • Sample integrity is highly sensitive to temperature during transport and storage.
  • Processing methods, including centrifugation speed and duration, affect results.
  • Automated sample handling lines may introduce unique preanalytical challenges.

Conclusions:

  • Strict adherence to standardized preanalytical procedures is necessary.
  • Optimized sample handling protocols ensure the accuracy of hemostasis testing.
  • Further research into automated systems' impact on sample quality is warranted.