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Updated: May 21, 2026

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents
10:53

Isolation of Human Atrial Myocytes for Simultaneous Measurements of Ca2+ Transients and Membrane Currents

Published on: July 3, 2013

Pharmacology of myocardial calcium-handling

Julia Vogler1, Lars Eckardt

  • 1Division of Rhythmology, Department of Cardiology and Angiology, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany. julia.vogler@ukmuenster.de

Wiener Medizinische Wochenschrift (1946)
|June 19, 2012
PubMed

Insights

Impaired myocardial calcium handling is key in heart diseases. Treatments aim to restore calcium homeostasis using current and novel pharmacologic agents targeting calcium-dependent pathways.

Area of Science:

  • Cardiovascular Pharmacology
  • Molecular Cardiology
  • Biomedical Science

Background:

  • Disturbed myocardial calcium (Ca2+) handling is a hallmark of cardiovascular diseases like heart failure and hypertrophy.
  • Abnormal Ca2+ handling also contributes to tachyarrhythmias.
  • Restoring myocardial Ca2+ homeostasis is a primary therapeutic goal.

Purpose of the Study:

  • To review current pharmacologic agents for restoring myocardial Ca2+ homeostasis.
  • To discuss the mechanisms of action of these agents.
  • To highlight emerging substances for cardiovascular disease treatment.

Main Methods:

  • Literature review of pharmacologic agents.
  • Analysis of mechanisms targeting Ca2+-dependent signaling pathways.
  • Synthesis of information on established and novel treatments.

Main Results:

  • Identified key pharmacologic strategies targeting myocardial Ca2+ homeostasis.
  • Detailed mechanisms of action for existing drugs.
  • Summarized potential of new therapeutic substances.

Conclusions:

  • Pharmacologic interventions targeting myocardial Ca2+ homeostasis are crucial for cardiovascular diseases.
  • Understanding Ca2+ handling mechanisms informs drug development.
  • Novel agents show promise for improved treatment of heart conditions.

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