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Updated: May 21, 2026
Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
Bioactivity and viscoelastic characterization of chitosan/bioglass® composite membranes
Sofia G Caridade1, Esther G Merino, Natália M Alves
13B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, 4806-909 Taipas, Guimarães, Portugal. sofia.caridade@dep.uminho.pt
Abstract:
Membranes of chitosan (CTS) and composite membranes of CTS with bioglass are prepared by solvent casting. The composite membranes are shown to induce the precipitation of apatite upon immersion in SBF. The biomineralization process is followed by measuring the variation of the viscoelastic properties of the membranes immersed in SBF, both online and offline. Non-conventional DMA is used to measure the change in the storage modulus, E', and the loss factor, tan δ, as a function of the immersion in SBF. A simple model is used to estimate the E' of the apatite layer formed in vitro that is about 130 MPa. This work shows that innovate mechanical tests can be useful to characterize the mechanical performance of composites under physiological conditions.
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