Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...

Ribosomal RNA Synthesis

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...

Types of RNA

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The molecular determinants of PABPC-mediated deadenylation rate.

bioRxiv : the preprint server for biology·2026

Same author

Global stabilization of the transcriptome in mitotic cells.

The EMBO journal·2026

Same author

mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth.

Genes & development·2026

Same author

The E3 ubiquitin ligase mechanism specifying targeted microRNA degradation.

Nature·2026

Same author

The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation.

bioRxiv : the preprint server for biology·2026

Same author

Derepression of a single microRNA target causes female infertility in mice.

Nucleic acids research·2026

Same journal

Complete sequencing of medaka genomes reveals the architecture of centromeric satellites, giant mobile elements, and sex chromosomes.

Genome research·2026

Same journal

Convergence and conflict among telomere specialized transposons across 60 million years of Drosophilid evolution.

Genome research·2026

Same journal

A unified analysis of cell type- and trajectory-associated pathways in single-cell data using Phoenix.

Genome research·2026

Same journal

Resf1 is required for proper placental development and configuration of trophoblast cell-specific heterochromatin.

Genome research·2026

Same journal

Telomere-driven replicative crisis is driven by large-scale changes in genomic architecture.

Genome research·2026

Same journal

Spatially informed reference-free cell-type deconvolution for spatial transcriptomics with SpatialCD.

Genome research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 21, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Long noncoding RNAs in C. elegans.

Jin-Wu Nam¹, David P Bartel

¹Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA.

Genome Research

|June 19, 2012

Summary

This summary is machine-generated.

Researchers identified 170 long intervening noncoding RNAs (lincRNAs) and 60 antisense noncoding RNAs (ancRNAs) in Caenorhabditis elegans. These noncoding RNAs exhibit stage-dependent expression and diverse functions, offering insights into invertebrate genomics.

More Related Videos

Hand Dissection of Caenorhabditis elegans Intestines

Hand Dissection of Caenorhabditis elegans Intestines

Published on: September 13, 2022

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

Related Experiment Videos

Last Updated: May 21, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

Hand Dissection of Caenorhabditis elegans Intestines

Hand Dissection of Caenorhabditis elegans Intestines

Published on: September 13, 2022

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Large-scale Gene Knockdown in C. elegans Using dsRNA Feeding Libraries to Generate Robust Loss-of-function Phenotypes

Published on: September 25, 2013

Area of Science:

Genomics
Noncoding RNA Biology
Invertebrate Zoology

Background:

Thousands of long noncoding RNAs (lncRNAs) are known in vertebrates, but their roles in invertebrates are less understood.
lncRNAs play crucial roles in various biological processes, including gene regulation and development.

Purpose of the Study:

To identify and characterize long noncoding RNAs (lncRNAs) in the invertebrate Caenorhabditis elegans.
To investigate the genomic features, expression patterns, and potential functions of lncRNAs in a nonvertebrate model organism.

Main Methods:

Utilized RNA-sequencing, poly(A)-site, and ribosome-mapping data for lncRNA identification.
Classified lncRNAs into long intervening ncRNAs (lincRNAs) and antisense ncRNAs (ancRNAs).
Analyzed sequence conservation, expression profiles, and association with small RNAs and protein-coding transcripts.

Main Results:

Identified 170 lincRNAs and approximately 60 ancRNAs in C. elegans.
lncRNA genes exhibited stage-dependent expression patterns, differing from protein-coding genes.
A subset of lincRNAs showed low sequence conservation and mapped antisense to endogenous siRNA clusters, suggesting a role in siRNA biogenesis.
The majority of lincRNAs were more conserved and associated with key developmental processes like dauer formation, male identity, and sperm development.

Conclusions:

This study provides a comprehensive catalog of lncRNAs in C. elegans, expanding our understanding of noncoding RNA genomics in invertebrates.
The identified lncRNAs represent a valuable resource for future functional studies, particularly those related to development and gene regulation in nonvertebrate systems.