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Related Experiment Video

Updated: May 21, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Intrasclera schwannoma.

Hamid Hosseini¹, Masoomeh Eghtedari, Mohammad Roozitalab

¹Shiraz University of Medical Sciences, Shiraz, Iran.

BMJ Case Reports

|June 19, 2012

Summary

Ocular schwannomas are rare tumors of the eye, often mistaken for malignant melanoma. Clinicopathologic examination confirmed intrascleral schwannoma in a patient with decreased vision.

Area of Science:

Ophthalmology
Pathology
Oncology

Background:

Schwannomas are rare tumors originating from Schwann cells, typically affecting peripheral nerves.
Ocular schwannomas are exceptionally uncommon, primarily arising from ciliary nerves and presenting as solitary, amelanotic lesions within the choroid, ciliary body, or sclera.

Observation:

A 41-year-old female patient presented with a 3-month history of decreased visual acuity in her right eye.
An amelanotic fundus lesion was identified on the nasal side of the left eye.
Initial diagnostic suspicion, based on clinical presentation, pointed towards malignant melanoma, leading to enucleation.

Findings:

Post-surgical clinicopathologic examination revealed findings consistent with an intrascleral schwannoma.
The lesion, initially suspected as malignant melanoma, was histopathologically confirmed as a benign schwannoma.

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Primary Culture of Human Vestibular Schwannomas

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Implications:

This case highlights the diagnostic challenges posed by rare ocular tumors, emphasizing that even with advanced imaging, certain fundus lesions can mimic amelanotic melanoma.
For ambiguous fundus lesions lacking definitive preoperative diagnosis, invasive procedures like fine needle aspiration should be strongly considered to guide surgical and therapeutic decisions.