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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
Published on: July 9, 2014
Varicella pneumonitis in an immunocompetent patient
1Department of Respiratory Medicine, Mater Hospital, Belfast, UK. izhaq@doctors.net.uk
Abstract:
Varicella zoster virus is known by many different names, including chickenpox virus, varicella virus, zoster virus and human herpes virus type 3, and it causes chickenpox. Primary chickenpox skin involvement is a benign and self-limiting condition. The incidence in the Western world is on the rise. Varicella pneumonitis is a potentially fatal complication. Immunocompromised patients develop aggressive lung disease, but immunocompetent can have serious pulmonary compromise. Timely ICU support, respiratory intervention and antiviral therapy play a key role in improving outcomes. Aciclovir is an established therapy for treating varicella-related illnesses and early commencement in patients with or at risk of complications can be beneficial. This case demonstrates, healthy individuals with chickenpox can develop varicella pneumonitis. Despite being immunocompetent, the patient had significant radiologic changes.
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