Related Experiment Video
Updated: May 21, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
Causative Drugs and Clinical Outcome in Stevens Johnson Syndrome (SJS), Toxic Epidermal Necrolysis (TEN), and SJS-TEN
Gomathy Sethuraman1, Vinod K Sharma, Pooja Pahwa
1Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
Background:
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the most severe adverse drug reactions in children.
Objectives:
The objective was to study the causative drugs and outcome in children with SJS, SJS-TEN overlap, and TEN.
Materials And Methods:
Retrospective analysis of all the in-patient records of children below 18 years of age with the diagnosis of SJS, SJS-TEN overlap, and TEN was carried out.
Results And Conclusions:
Twenty children were identified, eight patients each were diagnosed as SJS and TEN and four as SJS-TEN overlap. Multiple drugs were implicated in 15 cases while single drug was responsible in 5 cases. Antibiotics (40.7%) were implicated as the commonest cause followed by NSAIDS (25.9%) and anticonvulsants (7.4%). Seventeen patients recovered completely and three patients died.
Related Concept Videos
Drug Toxicity: Allergic Reactions
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Drug Toxicity: Risk factors
Drug Toxicity: Dose-Dependent Reactions
Drug Toxicity: Overview
