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In Vivo Single-Molecule Tracking at the Drosophila Presynaptic Motor Nerve Terminal
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Information processing and integration with intracellular dynamics near critical point.

Atsushi Kamimura1, Tetsuya J Kobayashi

  • 1Institute of Industrial Science, The University of Tokyo Tokyo, Japan.

Frontiers in Physiology
|June 19, 2012
PubMed
Summary

Cells achieve reliable responses to noisy signals by optimizing intracellular pathways near critical points. Cell-to-cell interactions and movement further enhance information processing and lead to emergent spatial organization in populations.

Keywords:
autophosphorylationcellular information processingcollective behaviorultrasensitivity

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Area of Science:

  • Cellular Biology
  • Systems Biology
  • Information Theory

Background:

  • Cells exhibit precise responses to external signals despite inherent noise.
  • Intracellular signaling pathways are crucial for interpreting these signals.
  • Cell-to-cell communication, like quorum sensing, also plays a role in population-level responses.

Purpose of the Study:

  • To investigate how cells achieve reliable information processing from noisy signals.
  • To explore the link between critical phenomena and efficient intracellular signaling.
  • To understand the role of cell-to-cell interactions in population-level information processing.

Main Methods:

  • Theoretical analysis of intracellular signaling reactions.
  • Mathematical modeling of information processing in single cells and populations.
  • Simulation of cell movement and its effect on spatial organization.

Main Results:

  • Optimal information processing in cells occurs near bifurcation points, suggesting a link to critical phenomena.
  • Cell-to-cell interactions enable efficient information integration at the population level.
  • Cell movement can lead to spontaneous emergence of spatial organization.

Conclusions:

  • Critical-like phenomena at the single-cell level are associated with efficient information processing.
  • Cell-to-cell interactions are vital for robust information processing in cell populations.
  • Emergent spatial organization arises from efficient population-level responses to signals.