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Updated: May 21, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
Lysine methylation and the regulation of p53
Simon M Carr1, Shonagh Munro, Nicholas B La Thangue
1Laboratory of Cancer Biology, Department of Oncology, Medical Sciences Division, University of Oxford, Headington, Oxford OX3 7DQ, U.K.
Abstract:
The p53 tumour suppressor protein functions as a guardian against genotoxic stress. This function is mediated in part by the transcriptional activation of genes involved in cell-cycle arrest, apoptosis, DNA repair and autophagy. The activity of p53 is regulated by a complex array of post-translational modifications, which function as a code to determine cellular responses to a given stress. In this chapter we highlight recent advances in our understanding of this code, with particular reference to lysine methylation, and discuss implications for future research.
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