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Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
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Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
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Neurogenesis and Regeneration of Nervous Tissue

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Related Experiment Video

Updated: May 21, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

What does the developing brain tell us about neural diseases?

Esther T Stoeckli1

  • 1Institute of Molecular Life Sciences and Neuroscience, University of Zurich, Zurich, Switzerland. esther.stoeckli@imls.uzh.ch

The European Journal of Neuroscience
|June 20, 2012
PubMed
Summary
This summary is machine-generated.

Drug development for brain disorders faces challenges due to a lack of targets. Understanding brain development offers new therapeutic targets for both neurodevelopmental and neurodegenerative diseases.

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Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

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Last Updated: May 21, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

Area of Science:

  • Neuroscience
  • Drug Discovery
  • Genetics

Background:

  • Brain disorders represent a significant global health burden, exceeding the combined costs of cardiovascular diseases, cancer, and diabetes.
  • Despite the high burden, pharmaceutical investment in brain disorder research is declining in Europe.
  • A critical barrier to drug development is the scarcity of identified drug targets for neural diseases.

Purpose of the Study:

  • To highlight the need for increased investment in understanding brain disorders.
  • To propose a shift towards strengthening basic research in neuroscience.
  • To underscore the potential of studying brain development for identifying novel therapeutic targets.

Main Methods:

  • Review of recent studies on brain development processes and genes.
  • Analysis of the link between developmental mechanisms and disease etiologies.
  • Synthesis of information on the current state of pharmaceutical investment in brain research.

Main Results:

  • The developing brain holds significant potential for identifying new drug targets.
  • Genes and processes involved in brain development are implicated in both neurodevelopmental and neurodegenerative diseases.
  • Basic research is crucial for uncovering the etiologies and pathogenetic mechanisms of brain disorders.

Conclusions:

  • A paradigm shift from translational to basic research is essential for future drug and therapy development for brain disorders.
  • Understanding the developing brain is key to addressing the unmet needs in treating neurological conditions.
  • Increased focus on fundamental neuroscience research can revitalize drug discovery efforts for brain diseases.