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Busseihydroquinones A-D from the roots of Pentas bussei
Milkyas Endale1, Annabel Ekberg, Hoseah M Akala
1Department of Chemistry, University of Nairobi , P.O. Box 30197-00100, Nairobi, Kenya.
Abstract:
Four new naphthohydroquinones, named busseihydroquinones A-D (1-4), along with a known homoprenylated dihydronaphthoquinone (5), were isolated from the CH(2)Cl(2)/MeOH (1:1) extract of the roots of Pentas bussei. Although the genus Pentas is frequently used by traditional healers for the treatment of malaria, only marginal activities against the chloroquine-sensitive (D6) and the chloroquine-resistant (W2) strains of Plasmodium falciparum were observed for the crude root extract and the isolated constituents of this plant.
