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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...

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Related Experiment Video

Updated: May 21, 2026

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts
15:43

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Published on: October 25, 2011

Atypical fibroxanthoma.

Mirjana Ziemer1

  • 1Department of Dermatology, Venereology and Allergology, University of Leipzig, Germany. mirjana.ziemer@medizin.uni-leipzig.de

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|June 20, 2012
PubMed
Summary
This summary is machine-generated.

Atypical fibroxanthoma (AFX) is a rare skin disease with a debated classification. This review clarifies its current diagnostic and therapeutic status, considering historical context and recent data.

Related Experiment Videos

Last Updated: May 21, 2026

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts
15:43

Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts

Published on: October 25, 2011

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Atypical fibroxanthoma (AFX) is a rare skin neoplasm.
  • Historically, AFX was considered a variant of malignant fibrous histiocytoma (MFH).
  • Re-evaluation of MFH and introduction of undifferentiated pleomorphic sarcoma (UPS) have increased controversy regarding AFX classification.

Purpose of the Study:

  • To provide an understanding of the current diagnostic criteria for AFX.
  • To review the contemporary therapeutic approaches for AFX.
  • To contextualize the present understanding of AFX within its historical evolution.

Main Methods:

  • Literature review of historical and current data on AFX.
  • Analysis of diagnostic criteria evolution.
  • Synthesis of therapeutic strategies based on recent evidence.

Main Results:

  • AFX classification remains debated, with evolving diagnostic criteria.
  • Current therapeutic strategies are based on available data and expert consensus.
  • Understanding AFX requires considering its historical classification changes.

Conclusions:

  • Clarifying the diagnostic and therapeutic landscape of AFX is crucial.
  • Ongoing research is needed to refine AFX classification and treatment.
  • This review consolidates current knowledge on AFX for clinicians and researchers.