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Related Experiment Video

Updated: May 21, 2026

Transurethral Induction of Mouse Urinary Tract Infection

Transurethral Induction of Mouse Urinary Tract Infection

Published on: August 5, 2010

Ketamine-associated urinary tract dysfunction: an underrecognized clinical entity.

Yongqing Lai¹, Song Wu, Liangchao Ni

¹Department of Urology, Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, PR China. yqlord @ 163.com

Urologia Internationalis

|June 20, 2012

Summary

This summary is machine-generated.

Recreational ketamine use is linked to severe urinary tract problems in young adults. Cessation of ketamine and sodium hyaluronate treatment may offer relief for ketamine-associated urinary dysfunction.

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Area of Science:

Urology
Toxicology
Clinical Medicine

Background:

Recreational ketamine use is rising among young adults.
Anecdotal reports suggest a link between ketamine use and lower urinary tract symptoms.
This study investigates severe urinary issues in chronic recreational ketamine users.

Purpose of the Study:

To describe severe lower urinary tract symptoms in patients with chronic recreational ketamine use.
To identify a potential relationship between recreational ketamine use and these symptoms.
To explore management strategies for ketamine-associated urinary dysfunction.

Main Methods:

Case series of 6 patients with chronic recreational ketamine use.
Detailed history, physical examination, and further investigations.
Urography, urodynamic studies, cystoscopy, and bladder biopsies were performed.

Main Results:

Patients presented with severe lower urinary tract symptoms.
Investigations revealed contracted bladders, detrusor instability, and chronic cystitis.
Urine cultures were sterile, ruling out infection.

Conclusions:

Ketamine-associated urinary tract dysfunction is an emerging clinical issue.
The exact pathological mechanism remains unknown.
Ketamine cessation combined with intravesical sodium hyaluronate shows potential for symptomatic relief.