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Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species

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Published on: October 15, 2013

Bacteraemia caused by Catabacter hongkongensis.

Kevin Smith¹, Sushil K Pandey, James E Ussher

¹Clinical Microbiology Laboratory, North Shore Hospital, Takapuna, Auckland, New Zealand. Kevin.Smith@waitematadhb.govt.nz

|June 20, 2012

Summary

A novel strain of Catabacter hongkongensis, an anaerobic gram-positive bacillus, was identified in a patient with a perforated appendix. This rare isolate exhibited an unusual inability to utilize mannose, challenging standard identification methods.

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Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS

Published on: July 11, 2016

Area of Science:

Microbiology
Bacteriology
Clinical Diagnostics

Background:

Catabacter hongkongensis is a gram-positive, anaerobic bacillus.
Anaerobic bacteria present diagnostic challenges in clinical microbiology.
Identification relies on phenotypic characteristics and molecular methods.

Observation:

A C. hongkongensis strain was isolated from blood cultures of a patient with a perforated appendix.
This isolate demonstrated a novel phenotype: inability to utilize mannose.
16S rRNA gene sequencing confirmed the isolate's identity.

Findings:

The identification of a mannose-negative C. hongkongensis strain is reported.
This finding expands the known phenotypic range of C. hongkongensis.
The case links C. hongkongensis bacteremia to gastrointestinal perforation.

Implications:

Phenotypic identification of rare anaerobic bacteria can be difficult.
Molecular methods like 16S rRNA sequencing are crucial for accurate identification.
C. hongkongensis should be considered in cases of bacteremia with gastrointestinal sources, especially with perforation.