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Using Chronic Social Stress to Model Postpartum Depression in Lactating Rodents

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The link between stress and feeding behaviour.

Jayanthi Maniam¹, Margaret J Morris

¹Pharmacology, School of Medical Sciences, University of New South Wales, Sydney NSW 2052, Australia.

Neuropharmacology

|June 20, 2012

Summary

This summary is machine-generated.

Stress impacts feeding responses bidirectionally by altering neuropeptides. Early life stress can have long-term effects on feeding behavior and gene expression, influenced by the hypothalamo-pituitary-adrenal axis.

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Area of Science:

Neuroscience
Endocrinology
Behavioral Science

Background:

Stress exposure is universal across the lifespan, with significant impacts on psychosocial behavior and feeding responses.
While late-life stress effects are documented, early-life stress impacts on feeding are less understood but can manifest later.
The hypothalamo-pituitary-adrenal (HPA) axis regulates both stress and feeding, sharing neural pathways.

Purpose of the Study:

To review neuropeptides regulating feeding behavior and their modulation by HPA axis hormones.
To discuss long-term stress-induced alterations in feeding behavior.
To explore epigenetic modifications in neuropeptide gene expression related to stress and feeding.

Main Methods:

Literature review focusing on neuropeptides, HPA axis, and feeding regulation.
Analysis of bidirectional feeding responses to stress.
Examination of hormonal and neuropeptide interactions.

Main Results:

Stress alters feeding responses bidirectionally (increase or decrease in intake).
Glucocorticoids, neuropeptides (NPY, α-MSH, AgRP, melanocortins), and hormones (leptin, insulin, ghrelin) interact to mediate these changes.
Cross-talk between feeding and HPA axis systems influences feeding behavior.

Conclusions:

The shared neuroanatomy of stress and feeding systems leads to complex interactions.
Long-term stress can induce persistent changes in feeding behavior and gene expression via epigenetic mechanisms.
Understanding these interactions is crucial for addressing stress-related feeding disorders.