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Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
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Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

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The effects of significant coronary stenosis and percutaneous coronary intervention on aortic stiffness

Nihat Kalay1, Deniz Elcik, Ali Doğan

  • 1Department of Cardiology, Medicine Faculty of Erciyes University, Kayseri, Turkey. nihatkalay@hotmail.com

Turk Kardiyoloji Dernegi Arsivi : Turk Kardiyoloji Derneginin Yayin Organidir
|June 20, 2012
PubMed

Insights

Aortic stiffness is elevated in patients with significant coronary stenosis. Percutaneous coronary intervention (PCI) reduces this stiffness, but it remains higher than in controls, indicating AS is a predictor of coronary stenosis.

Area of Science:

  • Cardiology
  • Vascular Physiology
  • Interventional Cardiology

Background:

  • Aortic stiffness (AS) is a known predictor of cardiovascular events.
  • The role of AS in patients with coronary stenosis undergoing percutaneous coronary intervention (PCI) is not well-defined.
  • AS may offer insights into coronary hemodynamic status.

Purpose of the Study:

  • To investigate the effects of coronary stenosis and PCI on aortic stiffness.
  • To determine if AS provides additional information about coronary hemodynamic status in patients with coronary stenosis.

Main Methods:

  • 107 patients undergoing coronary angiography were categorized into critical stenosis (≥50%), noncritical stenosis (<50%), and control groups.
  • Aortic stiffness was measured using carotid-femoral aortic pulse wave velocity (PWV).
  • Patients with critical stenosis underwent successful PCI with repeat PWV measurements.

Main Results:

  • Mean PWV was significantly higher in the critical group (9.4±2.2 m/sec) compared to noncritical (5.8±1.1 m/sec) and control (5.7±1.1 m/sec) groups.
  • Following PCI, PWV decreased by 24.4% (to 7.1±2.0 m/sec) but remained higher than controls.
  • PWV correlated with age, systolic blood pressure, and hemoglobin, and predicted significant stenosis.

Conclusions:

  • Significant coronary stenosis is associated with markedly increased aortic stiffness.
  • Successful PCI partially improves aortic stiffness.
  • Aortic stiffness is a valuable indicator in patients with coronary stenosis.
Abstract

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