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12:19
Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
Published on: June 7, 2024
Cyclotherapy: opening a therapeutic window in cancer treatment
1Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. ingeborg.vanleeuwen@ki.se
Oncotarget
|June 20, 2012
Abstract:
Cyclotherapy is a promising endeavor to improve cancer treatment by tackling the dose-limiting side effects of chemotherapy, especially for cancers harboring mutations in the TP53 tumor suppressor. In this particular context, pretreatment with a p53 activator halts proliferation in healthy tissue, while leaving the p53-deficient tumor susceptible to conventional chemotherapy.
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