Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Brain Imaging

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic Stimulation (TMS).

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Epilepsy surgery in pediatric patients with complex COL4A1/2-associated epilepsy.

Epileptic disorders : international epilepsy journal with videotape·2026

Same author

Reducing Motion Artifact in High Resolution 7 T MRI Using the Magnetic Resonance Minimal Motion ("MR-MinMo") Head Stabilization Device.

Magnetic resonance in medicine·2026

Same author

Association of behavioral problems and health-related quality of life in children with epilepsy.

Epilepsy & behavior : E&B·2026

Same author

Thalamic oscillations distinguish natural states of consciousness in humans.

Nature human behaviour·2026

Same author

Termination of super-refractory status epilepticus following stereo-EEG implantation.

Epileptic disorders : international epilepsy journal with videotape·2026

Same author

Determinants of accuracy in frame-based stereoelectroencephalography: the role of experience, workflow, and selective use of guiding devices.

Frontiers in neurology·2026

Search research articles

Related Experiment Video

Updated: May 21, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Imaging the interaction: epileptic discharges, working memory, and behavior.

Umair J Chaudhary¹, Maria Centeno, David W Carmichael

¹DCEE, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom; MRI Unit, Epilepsy Society, Chalfont St. Peter, SL9 0RJ, United Kingdom.

Human Brain Mapping

|June 20, 2012

Summary

This summary is machine-generated.

Interictal generalized epileptiform discharges may impair cognition. These discharges altered brain activity during a spatial working memory task, particularly in frontal lobe networks.

Keywords:

IED behavior working memory

More Related Videos

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Related Experiment Videos

Last Updated: May 21, 2026

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with Epilepsy

Published on: November 13, 2016

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Electromagnetic Source Imaging in Presurgical Evaluation of Children with Drug-Resistant Epilepsy

Published on: September 20, 2024

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays

Published on: May 15, 2018

Area of Science:

Neuroscience
Cognitive Science
Epilepsy Research

Background:

Interictal generalized epileptiform discharges (iGEGs) are associated with cognitive impairments in epilepsy.
Understanding the neural mechanisms underlying these impairments is crucial for developing targeted interventions.

Purpose of the Study:

To investigate the impact of iGEGs on task-related brain activity during a spatial working memory task.
To quantify changes in hemodynamic responses associated with iGEGs during cognitive tasks of varying complexity.

Main Methods:

Simultaneous video-electroencephalography (EEG) and functional imaging were employed.
Participants performed a spatial working memory task with increasing complexity.
Task-related hemodynamic responses were analyzed in the presence and absence of iGEGs.

Main Results:

The frequency of iGEGs increased with task complexity.
iGEGs did not correlate with task performance errors.
Hemodynamic responses in frontal lobe networks were reduced during iGEGs, while motor cortex and parietal lobe activity remained.
Task-related hemodynamic changes were observed in frontal-lobe-network, motor-cortex, precuneus, and parietal lobes without iGEGs.

Conclusions:

Generalized epileptiform discharges during demanding working memory tasks can alter cognitive-related hemodynamic responses.
Frontal lobe networks involved in working memory appear particularly sensitive to the disruptive effects of iGEGs.
These findings highlight potential neural mechanisms linking iGEGs to cognitive deficits in epilepsy.