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Subcortical electrostimulation to identify network subserving motor control.

Philippe Schucht1, Sylvie Moritz-Gasser, Guillaume Herbet

  • 1Department of Neurosurgery, Bern University Hospital, Bern, Switzerland.

Human Brain Mapping
|June 20, 2012
PubMed
Summary
This summary is machine-generated.

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Subcortical electrical stimulation during awake surgery reveals a complex network modulating motor control. This study identified widespread fronto-parietal pathways involved in motor function, challenging hierarchical models.

Area of Science:

  • Neuroscience
  • Neurosurgery
  • Motor Control

Background:

  • Cerebral motor control is increasingly understood as a network of specialized circuits, moving beyond hierarchical models.
  • Subcortical electrical stimulation during awake surgery offers a unique method to map white matter tracts crucial for motor function.

Purpose of the Study:

  • To investigate cortico-subcortical connectivity in cerebral motor control.
  • To report novel findings on motor modulatory responses evoked by subcortical stimulation.

Main Methods:

  • Subcortical electrostimulation mapping was performed in 21 patients undergoing awake surgery for low-grade gliomas.
  • Stimulation sites were localized using the anterior and posterior commissures method on brain schemas.
Keywords:
awake surgerymotor controlmotor mappingnegative motor networksubcortical electrostimulation

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Main Results:

  • Negative motor responses were evoked in 20/21 patients.
  • Additional motor responses included acceleration and positive motor effects.
  • Stimulation sites were primarily located anterior to the corticospinal tract, extending into frontal and parietal white matter.

Conclusions:

  • The findings suggest a modulatory influence of the stimulated fiber network on motor function.
  • The distribution of stimulation sites implies descending pathways from premotor areas.
  • A large-scale fronto-parietal motor control network is indicated, involving the internal capsule.