Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the

Regina Wai-Yan Choy1, Zhiliang Cheng, Randy Schekman

  • 1Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.

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Targeting proteins to the ER
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After folding, the ER assesses the quality of secretory and membrane proteins. The correctly folded proteins are cleared by the calnexin cycle for transport to their final destination, while misfolded proteins are held back in the ER lumen. The ER chaperones attempt to unfold and refold the misfolded proteins but sometimes fail to achieve the correct native conformation. Such terminally misfolded proteins are then exported to the cytosol by ER-associated degradation or ERAD pathway for...
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Golgi Apparatus

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Golgi Apparatus

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