Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Application of Linearization and Approximation01:29

Application of Linearization and Approximation

87
A drone flying through complex terrain often relies on more than one sensing method to estimate small changes in altitude. Along with direct measurements, air pressure provides a useful indirect indicator of vertical movement. Atmospheric pressure decreases as altitude increases, and this relationship is commonly described using an exponential model. Although accurate, converting pressure measurements into altitude values requires calculations that are too complex to perform repeatedly during...
87
Application of Antiderivatives: Linear Motion01:26

Application of Antiderivatives: Linear Motion

55
A derivative describes how one quantity changes with respect to another, such as how velocity changes over time. The reverse process, which recovers a quantity from its rate of change, is known as integration. In physics, integration is fundamental because it links related physical quantities, allowing acceleration, velocity, and displacement to be understood as connected aspects of motion.Consider a car traveling at a steady speed of 20 meters per second when an obstacle appears 800 meters...
55
Social Foundations of Self II: The Generalized Other01:20

Social Foundations of Self II: The Generalized Other

246
According to George Herbert Mead, as children progress beyond the game stage, they develop a more comprehensive understanding of societal rules and norms. This cognitive and social development enables them to internalize the expectations of the broader community, refining their ability to regulate behavior.Consistent participation in organized activities is crucial in helping children recognize that their actions are not isolated but contribute to a more significant, interconnected group...
246
Application of the Linear Momentum Equation01:15

Application of the Linear Momentum Equation

423
The application of the linear momentum equation can be used to analyze the forces needed to hold a 180-degree pipe bend in place with flowing water. In this case, water flows through the bend with a constant cross-sectional area of 0.01 square meters and a flow velocity of 15 meters per second. The pressure at the entrance is 0.2 Megapascals and the pressure at the exit is 0.16 Megapascals.
The goal is to determine the force components in the x and y directions to hold the pipe in place. Since...
423
Generalized Hooke's Law01:22

Generalized Hooke's Law

2.7K
The generalized Hooke's Law is a broadened version of Hooke's Law, which extends to all types of stress and in every direction. Consider an isotropic material shaped into a cube subjected to multiaxial loading. In this scenario, normal stresses are exerted along the three coordinate axes. As a result of these stresses, the cubic shape deforms into a rectangular parallelepiped. Despite this deformation, the new shape maintains equal sides, and there is a normal strain in the direction of the...
2.7K
Generalized Anxiety Disorder01:30

Generalized Anxiety Disorder

677
Generalized Anxiety Disorder (GAD) is a chronic condition characterized by excessive and uncontrollable worry that persists for at least six months, significantly interfering with daily functioning. Unlike situational anxiety, which arises in response to specific stressors, GAD often occurs without a clear cause. Individuals may experience disproportionate worry about work, health, or relationships. For instance, a person might continuously fear poor health despite normal medical evaluations or...
677

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic interplay between food addiction, psychological and behavioral factors, and weight-related measures: A longitudinal network analysis in developing youth.

Journal of behavioral addictions·2026
Same author

Correction: Association of intestinal mucosal barrier function with intestinal microbiota in Spleen-Kidney Yang Deficiency IBS-D mice.

Frontiers in microbiology·2026
Same author

Adaptive Integration of Incomplete Multimodal 3D Neuroimaging for Alzheimer's Prediction and Biomarker Discovery.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science·2026
Same author

A powerful representation learning method for enhanced analysis of incomplete multi-omics data.

NPJ systems biology and applications·2026
Same author

Melanoma-patient-derived xenograft multi-omics resource melPDomiX maps gain- and loss-of-function alterations.

Cell reports·2026
Same author

Reversing the Hydrogenation Pathways of Nitrogen-Containing Intermediates for the Kinetics-Matched Urea Electrosynthesis.

Angewandte Chemie (International ed. in English)·2026
Same journal

Comparing Adaptive Interventions under a General Sequential Multiple Assignment Randomized Trial Design via Multiple Comparisons with the Best.

Journal of statistical planning and inference·2026
Same journal

Variable Selection in Ultra-high Dimensional Feature Space for the Cox Model with Interval-Censored Data.

Journal of statistical planning and inference·2026
Same journal

On semi-supervised estimation using exponential tilt mixture models.

Journal of statistical planning and inference·2025
Same journal

Regression-Assisted Bayesian Record Linkage for Causal Inference in Observational Studies with Covariates Spread Over Two Files.

Journal of statistical planning and inference·2024
Same journal

Efficient inference of parent-of-origin effect using case-control mother-child genotype data.

Journal of statistical planning and inference·2024
Same journal

Distributed eQTL analysis with auxiliary information.

Journal of statistical planning and inference·2024
See all related articles

Related Experiment Video

Updated: Jan 28, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.7K

A Note on Generalized Functional Linear Model and Its Application.

Qi Long1

  • 1Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, U.S.A.

Journal of Statistical Planning and Inference
|June 20, 2012
PubMed
Summary
This summary is machine-generated.

This study introduces a new method for analyzing biomarker data in colorectal neoplasia studies, addressing measurement errors in functional predictors. The spline smoothing technique improves the accuracy of generalized functional linear models for complex biological data.

More Related Videos

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.6K
Linearization of the Bradford Protein Assay
06:35

Linearization of the Bradford Protein Assay

Published on: April 12, 2010

103.4K

Related Experiment Videos

Last Updated: Jan 28, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

3.7K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.6K
Linearization of the Bradford Protein Assay
06:35

Linearization of the Bradford Protein Assay

Published on: April 12, 2010

103.4K

Area of Science:

  • Biostatistics
  • Statistical modeling
  • Biomarker analysis

Background:

  • Biomarker studies for colorectal neoplasia often involve functional predictors measured with error.
  • Existing statistical models may not adequately account for measurement errors in functional data.
  • Accurate modeling is crucial for identifying disease-related biomarkers.

Purpose of the Study:

  • To develop and evaluate a statistical method for generalized functional linear models with error-prone functional predictors.
  • To address challenges posed by discrete design points and smooth functions in biomarker data.
  • To improve the estimation of functional predictors and slope functions in the presence of measurement error.

Main Methods:

  • A two-step spline smoothing procedure is proposed for estimating the true functional predictor and the slope function.
  • The method assumes smoothness of the functional predictor and the slope function.
  • Operating characteristics of the proposed method are theoretically derived.

Main Results:

  • The proposed two-step spline smoothing method effectively handles functional predictors measured with errors.
  • Simulation studies demonstrate the method's usefulness and accuracy.
  • The approach is validated through data analysis of a colorectal neoplasia biomarker study.

Conclusions:

  • The developed method provides a robust approach for analyzing functional data with measurement errors in biostatistical applications.
  • Spline smoothing offers an effective way to estimate underlying smooth functions in complex biomarker studies.
  • This methodology enhances the analysis of colorectal neoplasia biomarker data, potentially leading to better diagnostic or prognostic insights.