Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High-frequency ventilation in neonates.

K Tsuzaki1

  • 1Department of Anesthesiology, Keio University, Tokyo, Japan.

Journal of Clinical Anesthesia
|November 1, 1990
PubMed
Summary

High-frequency ventilation (HFV) in neonatal care shows mixed results. While potentially reducing barotrauma, a recent trial found no significant benefit over conventional methods, suggesting further research is needed.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paraoxonase-1 gene Q192R polymorphism and reactive oxygen metabolites.

The Journal of international medical research·2012
Same author

A gene polymorphism in acetyl-coenzyme A carboxylase beta may be associated with the C-reactive protein level in a prediabetic and diabetic population.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2011
Same author

UCP1 genetic polymorphism (-3826 A/G) diminishes resting energy expenditure and thermoregulatory sympathetic nervous system activity in young females.

International journal of obesity (2005)·2010
Same author

Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity.

Journal of endocrinological investigation·2009
Same author

Anesthesia-related mortality and morbidity over a 5-year period in 2,363,038 patients in Japan.

Acta anaesthesiologica Scandinavica·2003
Same author

[Annual study of perioperative mortality and morbidity for the year of 1999 in Japan: the outlines--report of the Japan Society of Anesthesiologists Committee on Operating Room Safety].

Masui. The Japanese journal of anesthesiology·2002

Area of Science:

  • Neonatal respiratory care
  • Mechanical ventilation strategies
  • Pediatric pulmonology

Background:

  • High-frequency ventilation (HFV) was explored for neonatal respiratory distress syndrome (RDS).
  • Early theories suggested HFV could lower airway pressure, reducing pulmonary barotrauma and chronic lung complications.
  • Conventional mechanical ventilation (CMV) is the standard for neonatal respiratory support.

Purpose of the Study:

  • To review the current status of high-frequency ventilation in neonatal respiratory care.
  • To evaluate the physiologic basis, clinical effectiveness, and complications of HFV in neonates.
  • To synthesize findings from early studies and a multicenter randomized trial.

Main Methods:

  • Literature search of MEDLINE and bibliographies for publications from 1980-1990.
  • Selection of studies on the physiologic background and clinical reports of neonatal HFV.
  • Evaluation of data on physiologic basis, clinical effectiveness, complications, and trial results.

Main Results:

  • Early studies suggested HFV might reduce barotrauma and chronic pulmonary complications in infants with RDS.
  • A recent multicenter randomized trial did not demonstrate significant improvement with HFV compared to conventional ventilation.
  • The trial noted frequent complications with HFV and suggested prioritizing conventional ventilation, though study design limitations warrant further investigation.

Conclusions:

  • High-frequency ventilation is beneficial for specific conditions like air leak syndrome, bronchopulmonary fistula, or during bronchoscopy.
  • The role of HFV as a general alternative to conventional mechanical ventilation remains controversial.
  • Further research is needed to clarify conflicting results and the precise place of HFV in neonatal respiratory support.

Related Experiment Videos