Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Study on kidney function in female workers exposed to perchlorethylene.

A Vyskocil1, S Emminger, J Tejral

  • 1Department of Hygiene, Medical Faculty, Charles University, Hradec Králové, Czechoslovakia.

Human & Experimental Toxicology
|November 1, 1990
PubMed
Summary

This study found that chronic exposure to tetrachlorethylene (TCE) in dry-cleaning workers did not cause kidney damage. While urinary lysozyme was elevated, other kidney function markers remained normal, suggesting TCE is not nephrotoxic.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C-reactive protein, chemerin, fetuin-A and osteopontin as predictors of cardiovascular risks in persons with psoriasis vulgaris.

Physiological research·2021
Same author

Variation of selected genotoxic and epigenetic markers due to therapeutic exposure to PAHs and ultraviolet radiation.

Bratislavske lekarske listy·2020
Same author

Serum Levels of Aryl Hydrocarbon Receptor, Cytochromes P450 1A1 and 1B1 in Patients with Exacerbated Psoriasis Vulgaris.

Folia biologica·2018
Same author

Roles of miR-31 and endothelin-1 in psoriasis vulgaris: pathophysiological functions and potential biomarkers.

Physiological research·2017
Same author

Elevated levels of circulating biomarkers of cell death (nucleosomes) in the patients with plaque psoriasis treated with the Goeckerman regimen.

Bratislavske lekarske listy·2014
Same author

Expression of soluble sCD163 in serum of psoriatic patients is modulated by Goeckerman therapy.

Allergologia et immunopathologia·2012

Area of Science:

  • Occupational Health
  • Toxicology
  • Nephrology

Background:

  • Dry-cleaning industry workers face chronic exposure to tetrachlorethylene (TCE), a common organic solvent.
  • Understanding the potential renal effects of occupational TCE exposure is crucial for worker safety.

Purpose of the Study:

  • To investigate biochemical markers of kidney damage in female workers chronically exposed to TCE.
  • To compare renal function markers between TCE-exposed workers and a non-exposed control group.

Main Methods:

  • Biochemical analysis of urinary markers (lysozyme, albumin, beta 2-microglobulin, etc.) in 16 female dry-cleaning workers and 13 controls.
  • Personal environmental monitoring to quantify time-weighted average TCE exposure levels (mean 157 mg m-3).

Related Experiment Videos

Main Results:

  • Elevated urinary lysozyme excretion was observed in the TCE-exposed group.
  • No significant differences were found in urinary albumin, beta 2-microglobulin, lactate dehydrogenase, total proteins, or glucose between groups.
  • No correlation was identified between TCE exposure levels and the measured biochemical parameters.

Conclusions:

  • Chronic occupational exposure to tetrachlorethylene (TCE) does not appear to cause significant renal damage in female dry-cleaning workers.
  • The observed increase in urinary lysozyme warrants further investigation but does not indicate overt nephrotoxicity in this cohort.