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Related Experiment Videos

Acute poisoning with methidathion: a case.

R Zoppellari1, L Targa, P Tonini

  • 1Department of Anaesthesia and Critical Care, S. Anna Hospital, Ferrara, Italy.

Human & Experimental Toxicology
|November 1, 1990
PubMed
Summary

This case study details methidathion poisoning, finding haemoperfusion ineffective for removing the organophosphate. Methidathion persisted in the body for days, highlighting challenges in treating severe organophosphate poisoning.

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Area of Science:

  • Toxicology
  • Pharmacology
  • Clinical Medicine

Background:

  • Acute poisoning cases require effective detoxification strategies.
  • Methidathion, an organophosphate pesticide, poses significant toxicological risks.
  • Understanding the pharmacokinetics of pesticide ingestion is crucial for patient management.

Observation:

  • A 50-year-old male ingested a large dose (6.2g) of methidathion.
  • Treatment involved haemoperfusion, gastric lavage, atropine, pralidoxime, and mechanical ventilation.
  • Methidathion was detected in plasma, urine, and gastric juice for extended periods post-ingestion.

Findings:

  • Haemoperfusion demonstrated minimal efficacy, removing only 0.22% of ingested methidathion.
  • Clinical deterioration correlated with plasma methidathion levels exceeding 100 µg/L, suggesting redistribution.

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  • Neuropathy target esterase (NTE) inhibition and delayed polyneuropathy were not observed.

    • Implications:

    • Haemoperfusion is not an effective method for clearing methidathion in acute poisoning.
    • The long persistence and redistribution of methidathion complicate treatment and prognosis.
    • Further research into optimal management strategies for severe organophosphate poisoning is warranted.