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Hemostasis parameters disturbances in healthy individuals with prehypertension

Dimitris Papadopoulos1, Iordanis Mourouzis, Athanasia Kotrotsou

  • 1ESH Excellent Center of Hypertension, Laiko University Hospital, Athens, Greece. jimpapdoc@yahoo.com

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|June 21, 2012
PubMed

Insights

Prehypertension (PH) is linked to blood clotting and clot breakdown issues in healthy individuals. These hemostasis disturbances may predict future cardiovascular events.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Hypertension Research

Background:

  • Prehypertension (PH) is associated with increased cardiovascular risk.
  • Essential hypertension involves hemostasis balance disturbances.
  • The impact of PH on hemostasis in healthy individuals requires examination.

Purpose of the Study:

  • To investigate the effect of PH on hemostasis parameters.
  • To compare hemostasis in healthy individuals with PH versus those with normal blood pressure (NBP).

Main Methods:

  • Study included 204 subjects: 78 with PH (Group A) and 126 with NBP (Group B).
  • Subjects were matched for age, sex, BMI, and serum lipid levels.
  • Hemostasis parameters measured included fibrinogen, thrombomodulin, plasminogen activator inhibitor-1 antigen, and tissue plasminogen activator antigen.

Main Results:

  • Plasminogen activator inhibitor-1 antigen and tissue plasminogen activator antigen levels were significantly higher in the PH group.
  • Plasma levels of fibrinogen and thrombomodulin were also significantly higher in the PH group compared to the NBP group.
  • These findings indicate hemostasis disturbances predisposing to hypercoagulability and impaired fibrinolysis in individuals with PH.

Conclusions:

  • Prehypertension is associated with hemostasis disturbances, suggesting a state of hypercoagulability and impaired fibrinolysis.
  • These hemostatic changes in PH may have prognostic value for future cardiovascular events.
  • Further research is needed to confirm the prognostic significance of these findings.

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