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Updated: May 21, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
Published on: May 26, 2011
Integrin triplets of marine sponges in human D2 receptor heteromers
Alexander O Tarakanov1, Kjell G Fuxe, Dasiel O Borroto-Escuela
1Russian Academy of Sciences, St. Petersburg Institute for Informatics and Automation, Saint Petersburg, Russia. tar@iias.spb.su
Abstract:
The evidence for the existence of receptor heteromers opens up a new field for a better understanding of neural transmission. Based on our theory, we have discovered main triplets of amino acid residues in cell-adhesion receptors of marine sponges, which appear also as homologies in several dopamine D2 receptor heteromers of human brain. The obtained results probably mean a general molecular mechanism for receptor-receptor interactions in heteromers originated from the lowest animals (marine sponges).
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