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Modeling non-spherical oscillations and stability of acoustically driven shelled microbubbles.
Jonathan Loughran1, Robert J Eckersley, Meng-Xing Tang
1Department of Bioengineering, Imperial College London, London SW7 2AZ, United Kingdom.
The Journal of the Acoustical Society of America
|June 21, 2012
Summary
This study models shelled microbubble oscillations under ultrasound. Shell properties significantly reduce surface mode amplitudes and the size range for these modes, impacting ultrasound imaging and drug delivery applications.
Area of Science:
- Acoustics
- Biophysics
- Materials Science
Background:
- Microbubbles are crucial for ultrasound imaging and targeted drug delivery.
- Their oscillation and destruction under ultrasound are key phenomena.
- Current models often neglect the influence of the microbubble shell.
Purpose of the Study:
- To develop and simulate a model for surface mode oscillations in shelled microbubbles.
- To investigate the impact of shell viscosity and elasticity on these oscillations.
- To compare the behavior of shelled versus shell-free microbubbles.
Main Methods:
- Developed a Boussinesq-Scriven model for shelled microbubble oscillations.
- Simulated bubble behavior across various sizes and acoustic pressures.
- Calculated the occurrence and timing of surface modes.
Main Results:
- Shelled microbubbles exhibit reduced surface mode amplitudes compared to shell-free bubbles.
- The range of bubble sizes supporting surface modes is narrower for shelled bubbles.
- Shell properties significantly alter microbubble dynamics under ultrasound.
Conclusions:
- The shell plays a critical role in microbubble acoustic response and stability.
- Findings have implications for optimizing contrast-enhanced ultrasound and drug delivery systems.
- The developed model provides a more accurate representation of microbubble behavior.
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