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Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

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Related Experiment Video

Updated: May 21, 2026

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

Recent insights in primary sclerosing cholangitis.

Cyriel Y Ponsioen1

  • 1Department of Gastroenterology & Hepatology, Academic Medical Center, Amsterdam, The Netherlands. c.y.ponsioen@amc.nl

Journal of Digestive Diseases
|June 21, 2012
PubMed
Summary

Primary sclerosing cholangitis (PSC) is a serious bile duct disease causing cirrhosis and increasing cancer risk. Currently, no effective medical treatments exist to halt its progression.

Area of Science:

  • Gastroenterology and Hepatology
  • Immunology
  • Oncology

Background:

  • Primary sclerosing cholangitis (PSC) is a chronic, progressive inflammatory disease affecting the bile ducts.
  • It leads to biliary obstruction, fibrosis, and potentially liver cirrhosis, a leading indication for liver transplantation in some regions.
  • PSC is associated with a significantly increased risk of hepatobiliary cancers, particularly cholangiocarcinoma.

Purpose of the Study:

  • To summarize the current understanding of Primary Sclerosing Cholangitis (PSC).
  • To highlight the disease's progression, associated risks, and current therapeutic limitations.
  • To underscore the need for effective treatments for PSC.

Main Methods:

  • Literature review and synthesis of existing research on PSC.

Related Experiment Videos

Last Updated: May 21, 2026

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis
04:38

Partial Bile Duct Ligation in the Mouse: A Controlled Model of Localized Obstructive Cholestasis

Published on: March 28, 2018

  • Analysis of epidemiological data and clinical outcomes.
  • Review of current therapeutic strategies and their efficacy.

    • Main Results:

    • PSC causes progressive biliary tract damage, leading to cirrhosis and liver failure.
    • The condition elevates the risk of cholangiocarcinoma and colorectal cancer, especially in patients with inflammatory bowel disease.
    • No current medical therapy has demonstrated efficacy in halting PSC progression.

    Conclusions:

    • Primary sclerosing cholangitis is a severe condition with significant morbidity and mortality.
    • The increased cancer risk associated with PSC necessitates vigilant monitoring and management.
    • There is an urgent unmet need for disease-modifying therapies for PSC.