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[Causes and consequences of glycated hemoglobin variability on pediatric population]

Maria Inês Santos1, Catarina Resende, Frederico Rosário

  • 1Consulta de Diabetologia Infantil, Serviço de Pediatria, Hospital de São Teotónio, Viseu, Portugal.

Acta Medica Portuguesa
|June 21, 2012
PubMed

Insights

Adolescents and children with longer duration of type one diabetes mellitus show higher hemoglobin A1c (HbA1c) levels. Poor metabolic control in pediatric diabetes can lead to microalbuminuria and lipid disorders.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Metabolic Disorders

Background:

  • Type one diabetes mellitus is a prevalent childhood disease with severe complications if poorly managed.
  • Hemoglobin A1c (HbA1c) is the key indicator for metabolic control, and understanding its variability is crucial.

Purpose of the Study:

  • To assess the impact of age and disease duration on HbA1c levels in pediatric patients.
  • To investigate the correlation between HbA1c, serum lipid profiles, and microalbuminuria.

Main Methods:

  • An observational, cross-sectional, and analytical study was conducted.
  • Data from pediatric diabetic consultations were analyzed, including patient demographics, disease duration, metabolic control, and complications.
  • Statistical analysis was performed using Excel 2003 and SPSS 15.0 with a 5% significance level.

Main Results:

  • Adolescents exhibited significantly higher HbA1c (8.4%) compared to younger children (7.8%).
  • Patients with diabetes exceeding five years had elevated HbA1c (9%) versus those with shorter duration (7.8%).
  • Microalbuminuria (9%) and dyslipidemia (10%) were observed, with significantly higher HbA1c in affected patients (9.7% and 10% respectively).

Conclusions:

  • Increased HbA1c levels are associated with adolescence and longer disease duration in pediatric type one diabetes.
  • Complications like microalbuminuria and dyslipidemia are evident even in pediatric patients with suboptimal metabolic control.
Abstract

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