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[Eosinophilic esophagitis: clinical expression at pediatric age]

Ana Luísa Rodrigues1, Ana Maria Palha, Ana Isabel Lopes

  • 1Serviço de Pneumologia, Hospitais da Universidade de Coimbra, Coimbra, Portugal.

Acta Medica Portuguesa
|June 21, 2012
PubMed

Insights

Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease affecting the esophagus in children and adults. Diagnosis requires biopsies showing high eosinophil counts, and treatment involves dietary changes and swallowed steroids.

Area of Science:

  • Gastroenterology
  • Immunology
  • Allergy

Background:

  • Eosinophilic esophagitis (EoE) is an emerging chronic esophageal inflammatory disease.
  • It affects both children and adults, presenting with varied symptoms across age groups.

Observation:

  • Pediatric symptoms include feeding disorders, vomiting, and abdominal pain.
  • Adolescent and adult symptoms typically involve dysphagia and esophageal food impaction.

Findings:

  • The exact cause of EoE is unknown, but Th2-mediated immuno-allergic mechanisms are suspected.
  • Diagnosis requires esophageal biopsies with >15 intraepithelial eosinophils/HPF and exclusion of GERD.

Implications:

  • Current treatments focus on allergen avoidance through diet and topical steroid therapy.
  • Understanding EoE's variability is crucial for diagnosis and long-term management in pediatric patients.

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