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Related Experiment Video

Updated: May 21, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Lin28 regulates HER2 and promotes malignancy through multiple mechanisms.

Chen Feng¹, Veronique Neumeister, Wei Ma

¹Department of Obstetrics, Gynecology and Reproductive Sciences, Yale Stem Cell Center, Yale University School of Medicine, New Haven, CT, USA.

Cell Cycle (Georgetown, Tex.)

|June 21, 2012

Summary

The RNA binding protein Lin28 stimulates the expression of HER2, a key protein in breast cancer. Lin28 overexpression predicts poor prognosis in breast cancer patients, highlighting its role in cancer progression.

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Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

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Published on: March 30, 2019

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Last Updated: May 21, 2026

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Exploring the Pharmacological Action and Molecular Mechanism of Salidroside in Inhibiting MCF-7 Cell Proliferation and Migration

Published on: June 9, 2023

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

Area of Science:

Oncology
Molecular Biology
Gene Regulation

Background:

Lin28 and Lin28B are RNA binding proteins linked to advanced cancers.
They are known to inhibit the tumor suppressor let-7 miRNA, contributing to cancer.
HER2 is a critical receptor tyrosine kinase in breast cancer cell proliferation and survival.

Purpose of the Study:

To investigate the role of Lin28 in regulating HER2 expression.
To explore the mechanisms by which Lin28 promotes cancer cell growth.
To determine the clinical significance of Lin28 expression in breast cancer prognosis.

Main Methods:

Posttranscriptional regulation analysis of HER2 mRNA.
Enforced expression studies in cancer cells.
Correlation analysis of Lin28 expression with clinical outcomes in primary breast tumors.

Main Results:

Lin28 was identified as a regulator of HER2 mRNA.
Lin28 stimulates HER2 expression at the posttranscriptional level.
Enforced Lin28 expression promoted cancer cell growth through multiple pathways.
Lin28 overexpression is a strong predictor of poor prognosis in breast cancer.

Conclusions:

Lin28 regulates HER2 expression posttranscriptionally, adding to known gene amplification mechanisms.
Lin28 overexpression is linked to poor clinical outcomes in breast cancer.
Lin28's pleiotropic gene regulation suggests a common theme of targeting multiple pathways in cancer.